On April 20, Matt O’Malley, of West Roxbury, will run to “conquer cancer” as a member of the Dana-Farber Marathon Challenge team in the 124th Boston Marathon.

O’Malley, along with more than 500 Dana-Farber Marathon Challenge teammates from across the United States and around the world, will run Massachusetts’ historic marathon route from Hopkinton to Boston to raise $6.25 million for cancer research at Dana-Farber Cancer Institute.

This year marks the 31st annual running of the Dana-Farber Marathon Challenge. One-hundred percent of the money raised by the Dana-Farber Marathon Challenge team goes to Dana-Farber’s Claudia Adams Barr Program in Innovative Basic Cancer Research, which supports “promising” science research in its earliest stages. The Dana-Farber Marathon Challenge has raised more than $100 million for the Claudia Adams Barr Program to date.

In 1990, Dana-Farber was among the first charity organizations to be recognized by the Boston Athletic Association, which organizes the Boston Marathon. The Dana-Farber Marathon Challenge team offers its members extensive fundraising support, training guidance from 1976 Boston Marathon men’s champion Jack Fultz and Boston-area training runs, plus volunteer opportunities for non-runners. Dana-Farber Marathon Challenge runners who are not time-qualified for the Boston Marathon receive an invitational entry into the race.

To contribute to the Dana-Farber Marathon Challenge, contact the Dana-Farber Marathon Challenge office at 617-632-1970, dfmc@dfci.harvard.edu or visit http://rundfmc.org.